domperidone regimen

[alfie]

Would anyone know the correct domperidone ahead regimen? Domperidone and ranitidine are all I have right now...

 

[Heart of Ice]

It's useless to go for an ahead regimen with domperidone it seems, as it doesn't accumulate. It's still fine but you'd want to do a stat dose. It also seems that domperidone does not react well with acid regulators. I don't remember if Stan''s guide mentions these things.

 

[Quarky00]

"A 2- to 3-fold accumulation AUC observed with repeated four times daily (every 5 hr) dosing for 4 days."

https://sanctioned-suicide.net/threads/my-planned-domperidone-ahead-regimen.18083/

I've now taken 4 doses of 20mg at 8 hour intervals and haven't noticed the same side effects as before. Maybe I was pushing it too much with the 4 daily doses at 5 hour intervals. On reflection, for the ahead regimen I'd recommend the suggested 3 daily doses for 48 hours. As everyone reacts differently, I'd also follow the advice given and do a small test at a low dosage beforehand just to make sure you don't have any bad reactions.

 

[Heart of Ice]

"A 2- to 3-fold accumulation AUC observed with repeated four times daily (every 5 hr) dosing for 4 days."

https://sanctioned-suicide.net/threads/my-planned-domperidone-ahead-regimen.18083/

Then again I might be wrong, of course.

"Distribution

Oral domperidone does not appear to accumulate or induce its own metabolism; a peak plasma level after 90 minutes of 21 ng/mL after two weeks oral administration of 30 mg per day was almost the same as that of 18 ng/mL after the first dose."

 

[Quarky00]

"Oral domperidone does not appear to accumulate or induce its own metabolism; a peak plasma level after 90 minutes of 21 ng/mL after two weeks oral administration of 30 mg per day was almost the same as that of 18 ng/mL after the first dose."

True - if doses are far apart.

Addressed in the thread I linked -

I dismissed it because it appears to relate to single 30mg daily dosages. Considering that the half life of domperidone is 7-9 hours and the doses are taken 24 hours apart, it's not surprising that little accumulation is observed.

And others -

Meto is always going to be more effective. If you're going to use Doperidone, try to build it into your system over the period of a week or ten days.

^ This is a long post containing lots of research, I've only quoted the bottom line .

All hearsay and speculations! ;)

 

[Berlin76]

Would anyone know the correct domperidone ahead regimen? Domperidone and ranitidine are all I have right now...

Best to go with Metoclopramide
Its stronger and it cross the bloodstream to the brains

 

[jgm63]

I have some notes here :

Spoiler: post-509925

https://sanctioned-suicide.net/threads/n-protocol-regime-regimen-notes.27092/post-509925

Note :

Domperidone is apparently not compatible with H2 blockers (eg ranitidine) / antacid, although I haven't researched in depth, so perhaps do some more research yourself.

It may be a reasonable compromise to use domperidone, and omit the H2 blockers / antacid, if there are reasons why you can't use metoclopramide. H2 blockers / antacid are not considered to be essential.

What country are you in ?
Perhaps there might be some OTC antiemetics you can get instead if you don't have time to order meto....

 

[jgm63]

I have some notes here :

Spoiler: post-509925

https://sanctioned-suicide.net/threads/n-protocol-regime-regimen-notes.27092/post-509925

Note :

Domperidone is apparently not compatible with H2 blockers (eg ranitidine) / antacid, although I haven't researched in depth, so perhaps do some more research yourself.

It may be a reasonable compromise to use domperidone, and omit the H2 blockers / antacid, if there are reasons why you can't use metoclopramide. H2 blockers / antacid are not considered to be essential.

What country are you in ?
Perhaps there might be some OTC antiemetics you can get instead if you don't have time to order meto....

Actually I found out some extra info, so my thoughts on this are slightly "refined".
Please see :

Spoiler: post-536270

https://sanctioned-suicide.net/threads/is-domstal-domperidone-good-enough-for-sn.29445/post-536270