Difference between metoclopramide and Domperidone? Do both speed up the emptying of the stomach?

[phersper]

Considering are both AE via dopamine antagonism of the D2 receptors, is one better than the other in some way? I've read meto speed up the passage of SN from stomach to smaller intestine, is it true or just broscience? In case it is true, does the same thing apply to Domperidone (Motilium)?

 

[Deleted member 65988]

They both do the same thing from a functional perspective but I think you won't go with either one.

 

[intr0verse]

Yes, they both have prokinetic properties, the difference is that domperidone doesn't cross the blood-brain barrier so it wouldn't have some of the side-effects some people might have from using metoclopramide, like extrapyramidal symptoms. This inability to cross the BBB shouldn't interfere with its antiemetic properties since the chemoreceptor trigger zone is outside of BBB.

 

[phersper]

Yes, they both have prokinetic properties, the difference is that domperidone doesn't cross the blood-brain barrier so it wouldn't have some of the side-effects some people might have from using metoclopramide, like extrapyramidal symptoms. This inability to cross the BBB shouldn't interfere with its antiemetic properties since the chemoreceptor trigger zone is outside of BBB.

Ok, you 100% sure about the fact that both have same prokinetic properties? In this case domperidone wins considering the fact it does not cross bbb and cause extra pyramidal symptoms, which can be awful (talking from experience).

They both do the same thing from a functional perspective but I think you won't go with either one.

"You won't go"? What you mean?

 

[intr0verse]

Ok, you 100% sure about the fact that both have same prokinetic properties? In this case domperidone wins considering the fact it does not cross bbb and cause extra pyramidal symptoms, which can be awful (talking from experience).

Yes. It seems domperidone scores better at accelerating the GI tract emptying while metoclopramide it's a bit stronger as an antiemetic, but nevertheless they are both effective antiemetics.