Hello, and tell me, are you scared about opening it up or it being expired for this? I don't think it will loose its effectiveness really, but it depends on your bodies tolerance and how it is impacted, as some meds don't fully work well for your system, and why you need somewhat heavier or smaller to heavier doses to test and try out, and I have overdosed on bismuth before a couple of weeks when I wanted to feel something, and it worked the first time, but when I tried it out again, it didn't, but using naproxen, it surprised me too... the reason it did this the first time is because I was already experiencing my first tries of it, and it was a chewable tablet, but if it was something bigger in capsulated, it's equally be as affective. it had the same 252 mg dose on each tablet and kept getting deeper and deeper into it even after I delt with that, but its effectiveness was lost because my dumb system sort of needed it that way, but it doesn't fully leave your system, and why when I took naproxen afterwards, even while the affect was much slower, it was something else, and I only took 20 pills out of 4 for bismuth until I stopped caring, because... obviously we don't like wanna be here... I think seeing how your body reacts gives into learning your body and what it deals with, because prazosin and escitalopram made me feel the most affect, and it was only 3 pills for prazosin at 10mgs with making me feel like iw as dying and escitalopram at 20 pills at 10 mugs... imagine that, and I haven't touched them before, but I know based on the first try, since it was already in my system, it'll still affect me... you'd need to try two things with the same impact!!