Best Drugs to overdose on?

[Hambo]

What would be the best drugs to overdose on? (if you had access to any drug).

I reckon Fentanyl would be up there, since it depresses the respiratory system

 

[clover___]

Proper veterinary-grade euthasol, there's a good reason the vet profession has such a high rate of successful suicide and having seen what it does to a dog, that near instant unconsciousness, I'm sold.