Prozac was the first one I tried and it made my life significantly better, but after a while they stopped working and I had to change to a different one. I've been taking ad's for 27years and the best ones for me were citalopram. The worst were Mirtazipine, (horrendous weight gain, agitation and suicidal ideation) and I'm currently taking Duloxetine which I'm up and down with because much of my depression currently is circumstantial.