Help Antiemetics for SN method

[UnluckyYogi]

Since I don't have access to prescription antiemetics like Meto..., I'm planning to use Dimenhydrinate, which is OTC antiemetic, and weed as well.
I've read on the PPH that weed can act as an antiemetic too.

My question is, will Dimenhydrinate and weed will be sufficient enough to minimize vomiting?
If Dimenhydrinate won't be sufficient enough, I have Amisulpride/Solian pills, will they help?

 

[andreamysk]

Since I don't have access to prescription antiemetics like Meto..., I'm planning to use Dimenhydrinate, which is OTC antiemetic, and weed as well.
I've read on the PPH that weed can act as an antiemetic too.

My question is, will Dimenhydrinate and weed will be sufficient enough to minimize vomiting?
If Dimenhydrinate won't be sufficient enough, I have Amisulpride/Solian pills, will they help?

From what I read here (not very up to date, but still useful in general principle) https://web.archive.org/web/2021091...ki/index.php?title=Sodium_Nitrite#Antiemetics Dimenhydrinate is not effective in this case. Of the three mentioned, Amisulpride is probably the one that could be useful, because it acts on the dopamine d2 receptors (this is the effective mechanism). The entire class of antipsychotics, however, is (more) effective if you were already taking it...

 

[UnluckyYogi]

From what I read here (not very up to date, but still useful in general principle) https://web.archive.org/web/2021091...ki/index.php?title=Sodium_Nitrite#Antiemetics Dimenhydrinate is not effective in this case. Of the three mentioned, Amisulpride is probably the one that could be useful, because it acts on the dopamine d2 receptors (this is the effective mechanism). The entire class of antipsychotics, however, is (more) effective if you were already taking it...

How long before drinking SN should I take Amisulpride? is 400mg pill enough?

 

[andreamysk]

From what I've read, this class of drugs (first and second generation antipsychotics) is effective not so much if taken only once, but if the active ingredient is already present in the plasma (so if you were already taking it regularly or starting to take it gradually until you reach the desired dose). That said, amisulpride seems to have good efficacy as a D2 receptor antagonist and reaches peak plasma concentrations 4 hours after taking it. I'm not a pharmacist or a doctor, but 400 mg seems like a pretty high dose to me, if you're taking it for the first time (the same drug, however injected into a vein, is prescribed in the US with an antiemetic function in doses of 4 mg)

It may be helpful to read https://sanctioned-suicide.net/thre...red-as-an-antiemetic-for-the-sn-method.38621/ (another drug, but similar reasoning applies)

 

[UnluckyYogi]

From what I've read, this class of drugs (first and second generation antipsychotics) is effective not so much if taken only once, but if the active ingredient is already present in the plasma (so if you were already taking it regularly or starting to take it gradually until you reach the desired dose). That said, amisulpride seems to have good efficacy as a D2 receptor antagonist and reaches peak plasma concentrations 4 hours after taking it. I'm not a pharmacist or a doctor, but 400 mg seems like a pretty high dose to me, if you're taking it for the first time (the same drug, however injected into a vein, is prescribed in the US with an antiemetic function in doses of 4 mg)

It may be helpful to read https://sanctioned-suicide.net/thre...red-as-an-antiemetic-for-the-sn-method.38621/ (another drug, but similar reasoning applies)

Thanks a lot!
Do you have a source where I can purchase Metoclopramide without prescription?

 

[andreamysk]

Thanks a lot!
Do you have a source where I can purchase Metoclopramide without prescription?

Unfortunately not. In some countries, however, it is sold over the counter, at half the prescription dose (5 mg).